Description

Pimozide 2mg

Pimozide (2 mg tablet) is used to treat severe motor and phonic tics associated with Tourette’s disorder, especially when other medications have been insufficient. It works by controlling the excessive dopamine activity in the brain, which helps reduce involuntary movements and sounds. Available in a pack of 100 tablets, this medication is manufactured by Intas and is typically prescribed when other therapeutic options have not provided adequate relief. Pimozide is also known under the brand names Orap and Mozep.

Pimozide mechanism of action

Pimozide is an antipsychotic medication primarily used to manage motor and vocal tics associated with Tourette’s syndrome. It functions by modulating dopamine activity in the brain, thereby reducing the frequency and intensity of tics.

Uses of Pimozide:

• Tourette’s Syndrome: Pimozide is indicated for patients with severe tics that interfere with daily functioning and have not responded adequately to other treatments.
• Off-Label Uses: In certain cases, pimozide has been used to treat conditions like schizophrenia and delusional disorders, though such uses should be under strict medical supervision.

Dosage:

• Adults: The initial recommended dose is 1 to 2 mg per day, taken in divided doses. The dosage may be increased every other day based on therapeutic response and tolerance, but it generally should not exceed 10 mg per day.
• Children (12 years and older): The starting dose is typically 0.05 mg/kg per day, with gradual increases every three days as needed. The maximum daily dose should not exceed 10 mg.

Side Effects:

Common side effects may include:

• Drowsiness
• Dry mouth
• Constipation
• Blurred vision
• Dizziness

Serious side effects can occur and require immediate medical attention:

• Tardive Dyskinesia: Involuntary, repetitive body movements that may become irreversible.
• Neuroleptic Malignant Syndrome: A rare but life-threatening condition characterized by high fever, muscle rigidity, and altered mental status.
• Cardiovascular Effects: Pimozide can cause QT interval prolongation, leading to serious heart rhythm disturbances.

Contraindications:

• Patients with congenital long QT syndrome or a history of cardiac arrhythmias.
• Individuals with low levels of potassium or magnesium in the blood.
• Concomitant use with medications that prolong the QT interval or inhibit CYP3A4 enzymes.

Precautions:

• Regular Monitoring: Patients should undergo periodic ECGs to monitor heart rhythm and blood tests to check electrolyte levels.
• Avoid Grapefruit: Consuming grapefruit or grapefruit juice can increase pimozide levels in the bloodstream, leading to potential toxicity.
• Pregnancy and Breastfeeding: Pimozide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Breastfeeding is not recommended while taking pimozide.

Drug Interactions:

• Pimozide should not be used with certain antibiotics, antifungals, antidepressants, and other medications that can affect heart rhythm or inhibit its metabolism. Always inform your healthcare provider of all medications and supplements you are taking.
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Administration:

• Pimozide is taken orally, with or without food. It’s essential to follow the prescribed dosing schedule and not to discontinue use abruptly without consulting a healthcare professional.

Storage:

• Store at room temperature, away from moisture and heat. Keep out of reach of children.

Conclusion:

Pimozide is a potent medication for managing severe tics in Tourette’s syndrome but requires careful monitoring due to its potential side effects and interactions. Always use this medication under the guidance of a qualified healthcare provider.

This information is intended for educational purposes and should not replace professional medical advice. Consult your healthcare provider for personalized guidance.

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